Molecular Mechanism of Baizhu-Tusizi Drugs in the Treatment of Polycystic Ovary Syndrome Based on Network Pharmacology
Objective To study the mechanism of Chinese medicine Baizhu-Tusizi in the treatment of polycystic ovary syndrome(PCOS)based on network pharmacology,in order to provide a basis for the development of new drugs and the application of classical formulas.Methods The database of Traditional Chinese Medicine Systems Pharmacology Platform(TCMSP)was used to obtain the main chemical components and targets of Baizhu and Tusizi,and ADME was used to select the active ingredients of Baizhu and Tusizi;PCOS targets were obtained through Gencards,PharmGkb,DisGeNET,DRUGBANK and other different databases,and protein interaction was studied on PCOS through the String platform,PPI network structure was established,and possible protein structures were deeply explored.The"drug-ingredient-target"was studied using Metascape technology,and the"Baizhu-Tusizi-PCOS-pathway"was established using Cytoscape 3.7.1 software.Rseults A total of 15 active ingredients were screened for Baizhu-Tusizi drugs,which acted on 198 predicted targets;2200 disease targets were screened;Wayne diagram obtained 136 common targets;Baizhu-Tusizi drugs played a regulatory role in regulating endocrine and ovarian function on the regulatory pathway of PCOS,including AGE-RAGE signaling pathway,IL-17 signaling pathway,MAPK signaling pathway,etc.Conclusion In the treatment of PCOS,Baizhu-Tusizi may regulate endocrine and ovarian function by participating in the regulation of AGE-RAGE signaling pathway,IL-17 signaling pathway,MAPK signaling pathway,etc.on AKT1,JUN,CASP3,MAPK8 and other targets,providing a basis for the clinical development and utilization of Baizhu-Tusizi drug pairs.
万方数据
维普
