摘要
目的 探讨血清间接胆红素(I-Bil)、肌钙蛋白Ⅰ(cTN Ⅰ)、肌酐(Crea)及血浆D二聚体(DD)水平在血栓性血小板减少性紫癜(TTP)患者中的表达及临床意义.方法 选取2019年1月-2022年12月我院收治的TTP患者35例作为试验组,另选同期35名健康志愿者作为对照组.比较两组血清I-Bil、cTN Ⅰ、Crea及血浆DD水平,分析上述指标与TTP患者血小板计数的关系.结果 试验组血清I-Bil、cTN Ⅰ、Crea及血浆DD水平均高于对照组,差异有统计学意义(P＜0.05);试验组经治疗缓解后,I-Bil、cTN Ⅰ、Crea及血浆DD水平均逐渐下降,均低于治疗前,差异有统计学意义(P＜0.05);相关性分析显示,I-Bil、cTN Ⅰ、Crea及血浆DD均与血小板计数呈负相关(r=-0.706、-0.664、-0.619、-0.531);试验组中病情未缓解的患者I-Bil、cTN Ⅰ、Crea及血浆DD水平呈持续升高趋势.结论 TTP患者血清I-Bil、cTNⅠ、Crea及血浆DD水平与病情变化密切相关,对上述指标的监测有助于对TTP患者的病情判断及预后评估.
Abstract
Objective To investigate the expression and clinical significance of serum indirect bilirubin(I-Bil),cardiac troponin Ⅰ(cTn Ⅰ),creatinine(Crea)and plasma D-dimer(DD)levels in patients with thrombotic thrombocytopenic purpura(TTP).Methods A total of 35 patients with TTP admitted to our hospital from January 2019 to December 2022 were selected as the experimental group,and 35 healthy volunteers in the same period were selected as the control group.The levels of serum I-Bil,cTn Ⅰ,Crea and plasma DD were compared between the two groups,and the relationship between the above indexes and platelet count in patients with TTP was analyzed.Results The levels of serum I-Bil,cTn Ⅰ,Crea and plasma DD in the experimental group were higher than those in the control group,and the differences were statistically significant(P＜0.05).After treatment and remission,the levels of I-Bil,cTn Ⅰ,Crea and plasma DD in the experimental group were gradually decreased,which were lower than those before treatment,and the differences were statistically significant(P＜0.05).Correlation analysis showed that I-Bil,cTn Ⅰ,Crea and plasma DD were negatively correlated with platelet count(r=-0.706,-0.664,-0.619,-0.531).The levels of I-Bil,cTn Ⅰ,Crea and plasma DD in patients with non-remission in the experimental group showed a continuous upward trend.Conclusion The levels of serum I-Bil,cTn Ⅰ,Crea and plasma DD in patients with TTP are closely related to the changes of the disease.The monitoring of the above indicators is helpful for the judgment and prognosis evaluation of patients with TTP.
基金项目
广西壮族自治区卫生健康委员会科研课题(Z20200381)
柳州市科技研究与技术开发计划项目(2016G020204)
广西壮族自治区卫生健康委员会科研课题(Z20200995)
广西壮族自治区卫生健康委员会科研课题(Z20190296)
万方数据