The Expression and Clinical Significance of DEK,MMP-7 and N-cadherin in Cervical Carcinoma
Objective To observe the expression of DEK,MMP-7 and N-cadherin in cervical carcinoma,and to explore their clinical significance.Methods From January 2016 to December 2021,80 cases of cervical squamous cell carcinoma tissues and 50 cases of adjacent normal cervical tissues were collected from Weifang Hospital of Traditional Chinese Medicine.The expression of DEK,MMP-7 and N-caherin proteins in the two groups was detected by immunohistochemistry.The relationship between the three proteins and the clinicopathological characteristics of cervical cancer was analyzed,and the correlation between the expression of the three proteins in cervical cancer was further analyzed.Results The expression of DEK,MMP-7 and N-cadherin in cervical cancer tissues was higher than that in adjacent normal cervical tissues(P＜0.05).The high expression of DEK,MMP-7 and N-caherin was related to the degree of differentiation,lymph node metastasis and TNM stage of cervical cancer(P＜0.05),but not to the age and tumor size of cervical cancer patients(P＞0.05).The expression of DEK in cervical cancer was positively correlated with the expression of MMP-7(r=0.269,P=0.008)and N-caherin(r=0.295,P=0.004).Conclusion DEK is related to the occurrence of cervical cancer,and is related to the tissue differentiation,invasion and metastasis of cervical cancer.Its mechanism of action in cervical cancer may be related to MMP-7 and N-caherin.
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