Expression and Significance of Serum IL-6,Interferon-y and Epidermal Growth Factor in Patients with Nasopharyngeal Carcinoma
Objective To study the expression and value of serum interleukin-6(IL-6),interferon-γ and epidermal growth factor in patients with nasopharyngeal carcinoma.Methods Sixty patients with nasopharyngeal carcinoma diagnosed and treated in our hospital from March 2019 to March 2022 were selected as the research objects,and 60 healthy people who underwent physical examination in our hospital during the same period were selected as the control group.Serum IL-6,interferon-γ and epidermal growth factor were detected in both groups.The levels of serum IL-6,interferon-y and epidermal growth factor were compared between the two groups.The differences of the above indexes in patients with different stages of nasopharyngeal carcinoma,different radiotherapy conditions and different prognosis were analyzed.The predictive value of different serum indicators for the prognosis of patients with nasopharyngeal carcinoma was analyzed.Results The levels of serum IL-6 and interferon-γ in patients with nasopharyngeal carcinoma were lower than those in the control group,and the epidermal growth factor was higher than that in the control group(P＜0.05).The levels of epidermal growth factor in patients with stage Ⅰ,Ⅱ,Ⅲ and Ⅳ showed an upward trend,while the levels of serum IL-6 and interferon-γ showed a downward trend(P＜0.05).The levels of serum IL-6 and interferon-γ in patients with radiotherapy tolerance were lower than those in patients with radiotherapy sensitivity,and epidermal growth factor was higher than that in patients with radiotherapy sensitivity(P＜0.05).The levels of serum IL-6 and interferon-γ in the dead patients were lower than those in the survival patients,and the level of epidermal growth factor was higher than that in the survival patients(P＜0.05).The sensitivity and specificity of combined detection of serum IL-6+interferon-γ+epidermal growth factor in predicting the prognosis of patients with nasopharyngeal carcinoma were higher than those of single detection of each index(P＜0.05).Conclusion There are certain characteristics of serum IL-6,interferon-γ and epidermal growth factor in patients with nasopharyngeal carcinoma.Clinically,patients with different stages,different radiotherapy conditions and different prognosis of nasopharyngeal carcinoma can be evaluated by detecting the levels of each index.In particular,the combined detection of serum IL-6,interferon-γ and epidermal growth factor can improve the predictive value of the prognosis of patients with nasopharyngeal carcinoma,and provide reference for clinical treatment.
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