Effect of Huangqi on Potassium Chloride Induced Hyperkalemia in Rabbits
Objective To study the effect of Huangqi injection on hyperkalemia rabbits,and preliminarily explore whether Huangqi injection has protective effect on hyperkalemia rabbits.Methods Rabbits were randomly divided into normal saline group,calcium gluconate group and Huangqi injection group.Hyperkalemia model was established by drug pretreatment and potassium chloride injection,respectively.The rabbits were pretreated with drugs and injected with potassium chloride to establish hyperkalemia model.The changes of heart rate and electrocardiogram of the three groups were observed,and the consumption of potassium chloride was recorded.Results Before pretreatment,the heart rate of rabbits was stable,and there was no obvious abnormal waveform in electrocardiogram.After 10 min of pretreatment,the three groups of rabbits showed baseline instability compared with that before pretreatment,the heart rate of the saline group and the Huangqi injection group was accelerated,and the heart rate of the calcium gluconate group was slowed down.After 20 min of pretreatment,the heart rate of rabbits in the three groups slowed down,ventricular fibrillation(sine wave)appeared in the saline group,QRS wave broadening and high T wave appeared in the Huangqi injection group and calcium gluconate group,and the Huangqi injection group was more obvious.There were significant differences in heart rate and potassium chloride consumption among the three groups(P＜0.05).Conclusion Huangqi injection has a certain protective effect on rabbit arrhythmia induced by hyperkalemia,and the protective effect is close to calcium gluconate.This has opened up a new way for clinical prevention of hyperkalemia.
万方数据
维普
