Objective To screen and sort out the literature related to autophagy of hepatoma cells in China in the past 20 years and conduct visual analysis of knowledge map,so as to reveal the research hotspots,historical evolution and future development trends in this field.Methods The related literatures on autophagy of hepatoma cells from January 2001 to February 2023 in China National Knowledge Infrastructure(CNKI),Wanfang and VIP database were searched.CiteSpace 6.1.R6 software was used to analyze the trend of literature number,author cooperation,institutional cooperation,keywords and time knowledge map visualization of the literatures that met the inclusion criteria and exclusion criteria.Results A total of 495 articles were included,the number of papers published in this field showed an overall upward trend,involving 462 authors and 287 research institutions.QIU Wei-hua and LIU Kai were the most productive authors,and there were six teams with close cooperation.Among them,QIU Wei-hua works most closely,and the institution with the largest volume of publication was Ruijin Hospital,Shanghai Jiao Tong University School of Medicine.In the past 5 years,the hot keywords mainly focused on mechanism,prognosis,anti-tumor and drug resistance;the key words formed 9 cluster tags,which were mainly summarized as the cellular mechanism of autophagy of hepatoma cells,drug therapy and literature research.Conclusion The research hotspots in this field are mainly focused on cellular mechanism and therapy,and there are many internal cooperation in this field,but a stable research team has not yet been formed among institutions.In the future,it is necessary to strengthen inter-agency cooperation and increase the opportunities and platforms for academic exchanges to further guide clinical practice.
维普
万方数据