Relationship Between Cystatin C,Ferritin and the Severity,Prognosis of Multiple Myeloma Bone Disease
Objective To explore the correlation between serum cystatin C,ferritin and the severity,prognosis of myeloma bone disease(MBD).Methods The clinical data of 152 MBD patients in Chaohu Hospital of Anhui Medical University and the First Affiliated Hospital of Anhui Medical University from October 2017 to October 2021 were retrospectively analyzed.According to the results of imaging examination,MBD patients were divided into groups A,B,C and D according to the severity of the disease.The levels of serum cystatin C and ferritin in the four groups were determined by immunoturbidimetry.The changes of serum indexes in the four groups were compared.Spearman method was used to analyze the correlation between serum cystatin C,ferritin and the severity of MBD.All patients were divided into survival group and death group according to their survival status,and Cox regression was used to analyze the prognostic factors.Results The levels of serum cystatin C and ferritin increased with the severity of the disease(P＜0.05).Spearman analysis showed that the levels of serum cystatin C and ferritin were positively correlated with the severity of MBD(r=0.735,0.801,P＜0.05).As of the follow-up time,98 of the 152 patients survived(64.47％)and 54 patients died(35.53％).The proportion of pathological fracture bone disease types,serum cystatin C and ferritin levels in the death group were higher than those in the survival group(P＜0.05).There were significant differences in the survival curves of serum cystatin C and ferritin between high and low levels(P＜0.05).Cox regression analysis showed that serum cystatin C,ferritin and pathological fracture were risk factors for the prognosis of MBD patients(P＜0.05).Conclusion The levels of serum cystatin C and ferritin increase with the severity of MBD,both of which are prognostic risk factors for MBD patients.
万方数据
维普
