Correlation Study of QRS Duration in Heart Failure with Preserved Ejection Fraction
Objective To study the relationship between QRS duration and heart failure with preserved ejection fraction(HFpEF).Methods A total of 87 patients with HFpEF who were admitted to the 940 th Hospital of Joint Logistics Support Force from January 2021 to January 2022 were selected as the heart failure group,and the heart failure group was divided into groups Ⅱ-Ⅳ according to the New York Heart Association(NYHA)cardiac function classification.In addition,53 healthy subjects in the same period were selected as the control group.The clinical data of each group were compared.Spearman correlation was used to analyze the relationship between QRS duration and clinical indicators.ROC curve was used to analyze the efficacy of QRS duration in the diagnosis of HFpEF.Results There was no significant difference in age,BMI,proportion of coronary heart disease,proportion of diabetes and FS among the groups(P＞0.05),while there were significant differences in gender,proportion of hypertension,proportion of atrial fibrillation,creatinine,QRS,QTC,LVEF,LAD,LVEDV,LVESV,QRS duration and NT-proBNP among the groups(P＜0.05).Spearman correlation analysis showed that QRS wave duration was positively correlated with age,LAD,LVEDV,LVESV and NT-proBNP,and negatively correlated with LVEF(P＜0.05).ROC curve analysis showed that the AUC of QRS wave duration in the diagnosis of HFpEF was 0.843(95％CI:0.772-0.915),the sensitivity and specificity were 88.50％and 71.70％,respectively,and the cut-off value was 98.5 ms;the AUC of NT-proBNP in the diagnosis of HFpEF was 0.979(95％CI:0.961-0.998),the sensitivity and specificity were 93.10％and 96.20％,respectively,and the cut-off value was 619.5 pg/ml;the combination of QRS duration and NT-proBNP had higher diagnostic value for HFpEF,with AUC of 0.984(95％CI:0.967-0.100),sensitivity and specificity of 92.00％and 98.10％,respectively.Conclusion The QRS duration in patients with HFpEF increases with the increase of NYHA classification.The combined detection of QRS duration and NT-proBNP can effectively improve the diagnostic efficiency of HFpEF.
QRS durationHeart failure with preserved ejection fractionHeart failure
万方数据
维普
