Effect of CYP2C19 Genotype on the Prognosis of Patients with Acute Cardiovascular and Cerebrovascular Infarction
Objective To investigate the distribution characteristics of CYP2C19 gene polymorphism in patients with acute cardiovascular and cerebrovascular infarction and its guiding value in clinical treatment.Methods A total of 225 patients with acute cardiovascular and cerebrovascular infarction admitted to Ordos Central Hospital from December 2017 to December 2022 were selected as the research objects.The CYP2C19 genotype was detected.The patients were divided into group A(fast metabolic type),group B(intermediate metabolic type)and group C(slow metabolic type)according to the speed of clopidogrel metabolic reaction.All patients received basic symptomatic treatment,supportive treatment and aspirin treatment,and received conventional dose of clopidogrel hydrogen sulfate(75 mg/d).The physiological and biochemical indexes,CYP2 C19 genotype and adverse events within 3 months after operation were compared among the three groups.Results There was no significant difference in physiological and biochemical indexes among the three groups(P＞0.05).Among 225 patients,84 patients and 20 patients carried CYP2C19*2 and*3 mutation heterozygotes respectively,and 13 patients and 0 patient carried CYP2C19*2 and*3 mutation homozygotes respectively.In group A,there were 104 patients of*1/*1 and 4 patients of*1/*17;in group B,there were 79 patients of*1/*2,20 patients of*1/*3 and 5 patients of*2/*17;in group C,there is 13 patients of*2/*2.The incidence of cardiogenic rehospitalization in group B was higher than that in group A and group C,and the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of other adverse events among the three groups(P＞0.05).Conclusion The prognosis of clopidogrel bisulfate anticoagulation in patients with acute cardiovascular and cerebrovascular infarction is affected by CYP2C19 gene polymorphism to a certain extent.CYP2C19 gene detection has important guiding value for clinical postoperative antiplatelet therapy,which needs further research.
CYP2C19 geneClopidogrelAcute cardiovascular and cerebrovascular infarction
万方数据
维普
