Expression and Significance of DEK,Wnt-1,GSK-3β in Cervical Squamous Cell Carcinoma
Objective To observe the expression changes of DEK,Wnt-1 and GSK-3β in cervical squamous cell carcinoma,and to explore the clinicopathological significance of DEK,Wnt-1 and GSK-3β in cervical squamous cell carcinoma.Methods A total of 100 patients with cervical squamous cell carcinoma diagnosed in Weifang Hospital of Traditional Chinese Medicine from January 2016 to December 2021 were selected,and the squamous epithelial tissue around the cancer was selected as the control group.Immunohistochemical method was used to observe the expression of DEK,Wnt-1 and GSK-3β protein in tissues,and the relationship between DEK,Wnt-1,GSK-3β and clinicopathological parameters was explored,the correlation between DEK and Wnt-1,GSK-3β were analyzed.Results Compared with normal cervical squamous epithelial tissues,DEK and Wnt1 were highly expressed in cervical squamous cell carcinoma tissues,and GSK-3β was lowly expressed.The high expression of DEK,Wnt-1 and the low expression of GSK-3β were related to the poor differentiation,lymph node metastasis and high TNM stage of the tumor(P＜0.05).Pearson correlation analysis showed that DEK was positively correlated with Wnt-1(r=0.304,P=0.001)and negatively correlated with GSK-3β(r=-0.289,P=0.002)in cervical squamous cell carcinoma.Conclusion The expression of DEK and Wnt-1 in cervical squamous cell carcinoma is increased,while the expression of GSK-3β is decreased.DEK is closely related to Wnt-1 and GSK-3β,and its abnormal expression is involved in the occurrence and development of cervical squamous cell carcinoma.
万方数据
维普
