The Expression Levels of Serum NLRP3 and Related Cytokines in HIV/TB Co-infected Patients
Objective To investigate the expression levels of NLRP3 and related cytokines in the serum of HIV/TB co-infected patients.Methods HIV,TB and HIV/TB patients admitted to the First People's Hospital of Kashgar Prefecture from January to December 2021 were collected as the research objects,which were set as HIV group,TB group and HIV/TB group,with 20 patients in each group.The expression levels of IL-6,IL-17,IL-22,IL-23 and TNF-α in serum of patients were detected by enzyme-linked immunosorbent assay,and the expression levels of NLRP3mRNA in serum of patients were detected by real-time fluorescence quantitative PCR.The laboratory indexes of each group were compared.Results The levels of IL-6,IL-17,IL-22 and NLRP3mRNA in HIV/TB group were higher than those in TB group,and the level of IL-23 was lower than that in TB group,the difference was statistically significant(P＜0.05).The levels of IL-6,IL-17,IL-22,IL-23,TNF-α and NLRP3 mRNA in HIV/TB group were higher than those in HIV group,,the difference was statistically significant(P＜0.05).Conclusion The imbalance of cytokines in patients with HIV/TB co-infection is more obvious than that in HIV patients and TB patients,which may be closely related to the occurrence and development of the disease.
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