Correlation Analysis Between Neutrophil Percentage-to-albumin Ratio and Coronary Heart Disease Complicated with Diabetes Mellitus
Objective To investigate the relationship between neutrophil percentage-to-albumin ratio(NPAR)and coronary heart disease(CAD)complicated with diabetes mellitus.Methods A total of 686 CAD patients who were hospitalized in Pingquan Hospital from January 2016 to December 2018 and underwent coronary angiography were included in the study.The patients were divided into CAD group(n=373)and CAD+T2DM group(n=313)according to whether they had type 2 diabetes mellitus(T2DM).In addition,the CAD+T2DM group was divided into low Gensini score group(Gensini score ≤7 scores),medium Gensini score group(Gensini score 8-16 scores)and high Gensini score group(Gensini score ≥17 scores)according to the Gensini score tertile.The clinical data of CAD group and CAD+T2DM group were compared,and the NPAR of different Gensini score tertiles was compared.The relationship between NPAR and Gensini score and its efficacy in predicting CAD+T2DM were analyzed.Results There were significant differences in age,WBC,BUN,NEUT,HDL,Gensini score and NPNR between CAD group and CAD+T2DM group(P＜0.05),there was no significant difference in the other indexes between the two groups(P＞0.05).The NPAR level in the high Gensini score group was higher than that in the low and medium Gensini score groups(P＜0.05),while there was no significant difference in NPAR level between the low Gensini score group and the middle Gensini score group(P＞0.05).ROC curve analysis showed that the area under the ROC curve of NPAR in predicting CAD+T2DM was 0.633(95％CI:0.591-0.675,P＜0.05),the Youden index was 0.29,the sensitivity was 57.20％,the specificity was 71.80％,and the best cut-off point was 1.4765.Spearman rank correlation analysis showed that NPAR was positively correlated with Gensini score(P＜0.05).Conclusion NPAR is closely related to CAD combined with T2DM,and NPAR has clinical application value in the diagnosis of coronary heart disease combined with diabetes mellitus.
万方数据
维普
