Research Status of FGF23/Klotho in the co-morbidities of Type 2 Diabetic Nephropathy and Osteoporosis
Type 2 diabetes mellitus(T2DM)and osteoporosis are two major metabolic diseases.The incidence of both diseases increases with age.However,diabetic nephropathy is one of the major microvascular complications of diabetes,and the development of diabetic nephropathy and osteoporosis is closely related to calcium and phosphorus metabolism.In recent years,there have been many reports on the co-pathogenesis of diabetic nephropathy and osteoporosis.The fibroblast growth factor 23(FGF23)/Klotho axis is one of the hot spots,its role in type 2 diabetic nephropathy and osteoporosis will be discussed in this article in order to provide a new target for early prevention or intervention of osteoporosis in diabetic nephropathy patients.
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维普
