Research Status of Intracavitary Perfusion in the Treatment of Malignant Pleural Effusion
Malignant pleural effusion(MPE)is a common complication of malignant tumors.Once it occurs,it indicates that the condition has entered a stage of deterioration.There are great difficulties in clinical treatment.Because it can often be accompanied by chest pain,chest tightness,wheezing and other symptoms,the tolerance is significantly reduced,which seriously affects the quality of life and prognosis of patients.At present,the treatment of intrapleural direct local perfusion of antitumor drugs is widely used.In this paper,the characteristics and clinical application of various drugs are analyzed from the aspects of pleural sclerosing agent,hyperthermia,chemotherapeutic drugs,biological immunosuppressive agents,traditional Chinese medicine preparations,anti-angiogenic agents and drug-loaded vesicles,in order to provide some reference for the future research and treatment of MPE.
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