首页|哌拉西林钠他唑巴坦钠相关腹泻的临床特征分析

哌拉西林钠他唑巴坦钠相关腹泻的临床特征分析

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目的 总结哌拉西林钠他唑巴坦钠引起腹泻的临床特征,为临床用药时快速、准确判断药品不良反应,保证安全、有效用药提供参考依据.方法 收集2014年1月-2022年12月贵港市人民医院收治的哌拉西林钠他唑巴坦钠致腹泻的26例病例,对性别、年龄分布、临床表现、用药时间、累积剂量、实验室检查结果、临床处理方法及转归等信息进行统计分析.结果 腹泻以大便次数增多、水样便为主,主要发生在距离用药后的2 d内,用药剂量小于36 g时,及时停药,对症治疗后,腹泻好转.结论 在使用注射用哌拉西林钠他唑巴坦钠后,出现相关性腹泻时,及时完善相关检查,评估病情,及时停药或更改治疗方案.
Analysis of Clinical Characteristics of Diarrhea Caused by Piperacillin/Tazobactam
Objective To summarize the clinical characteristics of diarrhea caused by piperacillin/tazobactam,and to provide reference for rapid and accurate judgment of adverse drug reactions in clinical medication,so as to ensure safe and effective medication.Methods A total of 26 cases of diarrhea caused by piperacillin/tazobactam admitted to Guigang City People's Hospital from January 2014 to December 2022 were collected.The gender,age distribution,clinical manifestations,medication time,cumulative dose,laboratory examination results,clinical treatment methods and outcomes were statistically analyzed.Results After medication(<36 g or less),most patients showed stool frequency increased and watery stools in two days,but improved after they stopped drugs and symptomatic treatment.Conclusion Clinically,perfect inspection to assess patient's condition,stopping medication timely or adjusting treatment plan are helpful to improve with piperacillin/tazobactam related diarrhea.

Piperacillin/tazobactamDiarrheaWatery stoolAntibiotic-associated diarrhea

彭水华、杨智文、廖乙媚、覃祖前、刘美珍、郭超

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广西医科大学第八附属医院/贵港市人民医院临床药学室,广西 贵港 537100

哌拉西林钠他唑巴坦钠 腹泻 水样便 抗菌药物相关性腹泻

2024

医学信息
国家卫生部信息化管理领导小组 中国电子学会中国医药信息学分会 陕西文博生物信息工程研究所

医学信息

影响因子:0.161
ISSN:1006-1959
年,卷(期):2024.37(4)
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