The Clinical Significance of Immunoglobulin and NLR,PLR in Patients with Frequent Exacerbation of Chronic Obstructive Pulmonary Disease
Objective To investigate the clinical significance of immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM),neutrophil/lymphocyte ratio(NLR)and platelet/lymphocyte ratio(PLR)in patients with frequent exacerbation of chronic obstructive pulmonary disease.Methods A total of 109 patients with acute exacerbation of chronic obstructive pulmonary disease who were admitted to our hospital from October 2022 to June 2023 were selected as AECOPD group,and 70 patients with stable chronic obstructive pulmonary disease were selected as SCOPD group.In addition,70 healthy subjects during the same period were selected as control group.AECOPD group was divided into the mild-moderate group(GOLD type 1-2)and severe-extremely severe group(GOLD type 3-4)according to the GOLD classification,and they were divided into frequent exacerbation group(≥2 times)and infrequent exacerbation group(＜2 times)according to the frequency of acute exacerbation in the previous year.The levels of IgA,IgG,IgM,NLR and PLR were compared among the groups.The correlation between the above indicators and the frequency of acute exacerbation in the previous year and FEV1％pred was analyzed.And the predictive efficiency of the above indicators was evaluated by the receiver operating characteristic curve.Results There were significant differences in the levels of IgA,IgG,IgM,NLR and PLR among AECOPD group,SCOPD group and control group(P＜0.05).There were significant differences in the levels of IgA,IgG,NLR and PLR between the mild-moderate group and the severe-extremely severe group(P＜0.05),but there was no significant difference in IgM level between the two groups(P＞0.05).There were significant differences in the levels of IgA,IgG,NLR and PLR between the frequent exacerbation group and the infrequent exacerbation group(P＜0.05),but there was no significant difference in IgM level between the two groups(P＞0.05).Correlation analysis showed that IgA and IgG were negatively correlated with the frequency of acute exacerbation in the previous year(P＜0.05),and positively correlated with FEV1％pred(P＜0.05);NLR and PLR were positively correlated with the frequency of acute exacerbation in the previous year(P＜0.05),and negatively correlated with FEV1％pred(P＜0.05);IgM was not correlated with the frequency of acute exacerbation in the previous year and FEV1％pred(P＞0.05).ROC curve analysis showed that the area under the curve of IgA、IgG、NLR、PLR predicting frequent acute exacerbation of COPD were 0.667,0.716,0.700 and 0.722,respectively.Conclusion IgA,IgG,NLR and PLR were correlated with frequent exacerbation and lung function index in AECOPD patients,which provided a reference value for evaluating the condition of AECOPD patients.
Chronic obstructive pulmonary diseaseImmunoglobulinFrequent exacerbationLung function
万方数据
维普
