Diagnostic Value of TCT and Biopsy Pathology in Early Cervical Cancer and Cervical Intraepithelial Neoplasia
Objective To explore the diagnostic value of thinprep cytologic test(TCT)and biopsy pathology in early cervical cancer and cervical intraepithelial neoplasia(CIN).Methods Among the 13 000 subjects who underwent TCT screening in Tianjin Baodi District People's Hospital from January 2021 to December 2022,2200 patients with positive results underwent biopsy pathology.The diagnostic results of TCT and biopsy pathology were compared,and the diagnostic coincidence rate,consistency and diagnostic value(diagnostic sensitivity,specificity and accuracy)of CIN and cervical cancer were analyzed.Results The coincidence rate of TCT and biopsy pathology in the diagnosis of CIN was 61.92％(805/1300),and the coincidence rate of TCT and biopsy pathology in the diagnosis of cervical cancer was 79.17％(19/24).By Kappa test,TCT and pathological biopsy had good consistency in the diagnosis of CIN(Kappa=0.603,P＜0.05),TCT and pathological biopsy had good consistency in the diagnosis of cervical cancer(Kappa=0.728,P＜0.05).The sensitivity,specificity and accuracy of pathological biopsy in the diagnosis of CIN and cervical cancer were higher than those of TCT(P＜0.05).Conclusion TCT and biopsy pathology have a high coincidence rate in the diagnosis of CIN and cervical cancer,and the diagnostic consistency between the two is good,but the differential diagnosis value of biopsy pathology is more higher.
Cervical cancerCervical intraepithelial neoplasiaThinprep cytologic testBiopsy pathologyConsistency of diagnosis
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