Exosomes,as membranous lipid vesicles,are capable of fusing with intracellular multicellular bodies released into the extracellular environment.Exosomes derive from bone marrow mesenchymal stem cells play a role in bone remodeling by regulating the proliferation and differentiation of osteoblasts and have become an effective method for the treatment of bone metabolic diseases.In this review,we summary the regulatory effect of bone marrow mesenchymal stem cell-derived exosomes on bone regeneration and the research progress of bone marrow mesenchymal stem cell-derived exosomes on bone regeneration after treatment with drugs and biological methods,providing theoretical basis for the clinical treatment of bone metabolic diseases.
关键词
骨髓间充质干细胞/外泌体/成骨分化/骨再生/骨质疏松症
Key words
Bone marrow mesenchymal stem cells/Exosomes/Osteogenic differentiation/Osteanagenesis/Osteoporosis
维普
万方数据