Value of Systemic Inflammation Response Index for the Efficacy and Prognostic Evaluation of Multiple Myeloma Patients
Objective To explore the role of systemic inflammatory response index(SIRI)in the efficacy and prognosis of newly treated MM patients receiving PDD regimen.Methods The clinical data of 110 newly treated MM patients who received PDD regimen from December 2015 to December 2021 were collected,and the best cutoff value was calculated by the working characteristic curve of the subjects,and the patients were divided into high SIRI group and low SIRI group.Kaplan-Meier survival curve was used to analyze the survival time of the two groups.Univariate and multivariate Cox regression models were used to analyze the prognostic factors of newly diagnosed MM.Results ①ROC curve analysis showed that the optimal cut-off value of SIRI was 1.03×109/L,including 42 cases in the high SIRI group and 68 cases in the low SIRI group.There were significant differences in age,percentage of bone marrow plasma cells,albumin and serum calcium between the high SIRI group and the low SIRI group(P＜0.05).②After 4 courses of treatment,the total effective rate of the high SIRI group was lower than that of the low SIRI group(P＜0.05).③Univariate analysis showed that serum calcium,ISS stage,β2-MG,creatinine,P53 deletion,RB1 deletion,D13S319 deletion and high SIRI were the influencing factors of PFS(P＜0.05);high SIRI,β2-MG,creatinine,P53 deletion and D13S319 deletion were the influencing factors of OS(P＜0.05).④Multivariate analysis showed that high SIRI,RB1 deletion and β2-MG were independent risk factors for PFS(P＜0.05);high SIRI and β2-MG were independent risk factors for OS(P＜0.05).Conclusion Increased SIRI is an independent poor prognostic factor in newly diagnosed MM patients.
万方数据
维普
