Correlation Between Diabetic Retinopathy and Diabetic Nephropathy by SPECT Imaging Technique
Objective To explore the correlation between diabetic retinopathy(DR)and diabetic kidney disease(DKD)by SPECT imaging.Methods A retrospective analysis of 250 patients with type 2 diabetic(T2DM)retinopathydiagnosed in Ziyang Central Hospital from March 2022 to April 2023 was performed.According to the DR staging criteria established by the World Health Organization,the patients were divided into five groups:non-DR(Non-DR)group,mild NPDR group,moderate NPDR group,severe NPDR group and PDR group,with 50 patients in each group.Glomerular filtration rate(GFR)was measured by 99m Tc-DTPA renal dynamic imaging in 115 males(230 eyes)and 135 females(270 eyes).The levels of TG,TC,HDL-C,LDL-C,HbA1c,Scr,BUN,UAlb,ACR,mALb and GFR in different DR groups were compared,as well as the incidence of DKD in non-DR,mild NPDR,moderate NPDR,severe NPDR and PDR groups.Results Compared with non-DR group,the levels of HbA1c,TG,TC,LDL-C,Scr,BUN,UAlb and ACR in mild,moderate and severe NPDR and PDR groups increased gradually,while HDL-C and GFR decreased gradually(P＜0.05).Logistic regression analysis showed that DR was significantly correlated with Scr,BUN,UAlb,ACR and GFR(P＜0.05).In DR patients,the overall incidence of DKD was 43.24％.Compared with non-DR,the incidence of DKD in mild,moderate,severe NPDR and PDR groups increased gradually(P＜0.05).The analysis of renal dynamic SPECT imaging technology showed that compared with no obvious DR,the renal area and renal depth of mild,moderate,severe NPDR and PDR groups gradually increased,and the blood perfusion rate,absorption rate and GFR gradually decreased(P＜0.05).There was no significant difference in peak time among the groups(P＞0.05).Conclusion In DR patients,early use of SPECT imaging technology for kidney disease screening can early and non-invasively screen out DKD.Timely intervention measures will effectively delay the development of DKD and improve the quality of life of diabetic patients.
万方数据
维普
