Diagnostic Value of Serum Cystatin C,Heparin-binding Protein,and SOFA Score for Acute Kidney Injury in Patients With Sepsis
Objective To explore the value of serum cystatin C(sCysC),heparin-binding protein(HBP)and sequential organ failure score(SOFA)in the diagnosis of acute kidney injury(SA-AKI)in adult patients with sepsis.Methods A retrospective analysis was performed on 76 patients with sepsis admitted to the Intensive Care Unit,Wujin Hospital Affiliated to Jiangsu University from December 2020 to August 2022.The patients were divided into AKI group(35 patients)and non-AKI group(41 patients)according to whether they had acute kidney injury(AKI).The related indicators between the two groups were compared.Logistic regression analysis was used to explore the risk factors of acute kidney injury in patients with sepsis.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of sCysC,blood HBP and SOFA scores for AKI in patients with sepsis.Results The proportion of vasoactive drugs,the proportion of mechanical ventilation,sCysC,HBP and SOFA scores in the AKI group were higher than those in the non-AKI group(P＜0.05).Among them,sCysC,HBP and SOFA scores were independent factors affecting AKI in patients with sepsis(P＜0.05);the AUC of sCysC,HBP,SOFA score and their combined detection in predicting AKI in patients with sepsis were 0.671,0.710,0.716 and 0.815,respectively.The combined AUC of sCysC,HBP and SOFA score was larger than that of sCysC and HBP(P＜0.05).Conclusion sCysC,HBP combined with SOFA score have high clinical application value in the diagnosis of SA-AKI patients,which may provide reference for the treatment of SA-AKI patients and reduce the incidence of poor prognosis.
万方数据
维普
