Clinical Phenotype Analysis of Metabolically Healthy Obesity in Patients Undergoing Bariatric Surgery
Objective To analyze the clinical and phenotypic characteristics of metabolically healthy obesity(MHO)patients who underwent bariatric surgery.Methods Clinical data were retrospectively collected from 1220 obese patients(1039 patients were finally included)who underwent bariatric surgery at the Department of Metabolic and Bariatric Surgery,Xuzhou Medical University Hospital from January 2019 to June 2022.Patients were divided into metabolically healthy obesity(MHO)and metabolically unhealthy obesity(MUO)groups based on diagnostic criteria.Differences in clinical data between the two groups and factors affecting MUO were analyzed using logistic regression.Results The proportion of MHO in patients undergoing bariatric surgery was 10.49％.Age,systolic blood pressure,diastolic blood pressure,fasting blood glucose,glycosylated hemoglobin,triglyceride,aspartate aminotransferase,alanine aminotransferase and cortisol in MHO group were lower than those in MUO group,while high density lipoprotein,total protein and albumin were higher than those in MUO group(P＜0.05).Multivariate logistic regression analysis showed that age(OR＜1,P＜0.05)was an independent risk factor for MHO,and total protein level(OR＞1,P＜0.05)was a protective factor for MHO.Conclusion MUO should not be misinterpreted as an obese population without any health impairment.Obese individuals diagnosed with MHO are still a sign to start treatment,but whether MHO patients need to undergo weight reduction metabolic surgery and the efficacy of performing surgery still needs further research.
万方数据
维普
