Correlation Between Systemic Immune Inflammatory Index and Prognosis of Patients with Chronic Kidney Disease
Objective To investigate the correlation between systemic immune inflammation index(SII)and prognosis of patients with chronic kidney disease(CKD).Methods The clinical data of 174 patients with CKD admitted to the Department of Nephrology,Chaohu Hospital of Anhui Medical University from January 2017 to January 2019 were retrospectively analyzed,and the SII value was calculated.According to the level of SII,the patients were divided into low SII group(SII ≤450.68)and high SII group(SII＞450.68),and the clinical data of the two groups were compared.The median renal survival time of the two groups was compared by Kaplan-Meier survival curve.Univariate and multivariate Cox regression models were used to analyze the prognostic factors of patients with CKD.Results The proportion of CKD stage 4 and 5,WBC,Plt,24-hour urinary protein quantity,Scr,BUN,CycC and PA in the high SII group were higher than those in the low SII group,while Alb was lower than that in the low SII group,and the differences were statistically significant(P＜0.05).Kaplan-Meier survival curve analysis showed that the median renal survival in the high SII group was shorter than that in the low SII group(25.83 months vs.67.61 months,P＜0.05).Univariate analysis showed that CKD stage,hypertension,diabetes,anemia,24-hour urinary protein quantity,UA,TG,and SII were all influencing factors for the prognosis of CKD patients(P＜0.05).Multivariate analysis showed that CKD stage,anemia,24-hour urinary protein quantity,UA and SII were independent risk factors affecting the prognosis of CKD patients(P＜0.05).Conclusion There is a certain correlation between SII and the prognosis of patients with CKD.High level of SII may indicate poor prognosis of patients with CKD.
万方数据
维普
