Research Progress of Targeted Microglia in the Treatment of Radiation-induced Brain Injury
Radiation-induced brain injury(RIBI)is a serious complication of neurological deficits in patients with head and neck cancer after radiotherapy.It can be manifested as acute adverse reactions such as headache,drowsiness and memory loss in the early stage,and cognitive dysfunction in the long term.At present,the pathogenesis of RIBI is not clear,and inflammatory immune response,vascular injury and demyelination are closely related to the pathogenesis of RIBI.Microglia are innate immune cells in the brain,which can act on the whole pathophysiological process of various central nervous system diseases,and ultimately affect the outcome of the disease.In recent years,studies on the treatment of diseases by targeting microglia have emerged one after another.This article reviews the research progress on the potential mechanisms of colony stimulating factor 1 receptor(CSF1R)inhibitors,mainly oral drugs PLX5622 and PLX3397,and targeted depletion of microglia in the treatment of RIBI.
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