Research Progress of CIRBP/TLR4/MyD88/NF-κB Signaling Pathway in Gestational Diabetes Mellitus
The number of patients with gestational diabetes mellitus(GDM)is increasing year by year,which not only increases the incidence of adverse pregnancy outcomes,but also has a negative impact on the health of pregnant women and their offspring,causing a greater burden on society.However,the pathogenesis of GDM has not been fully elucidated.Existing studies suggest that insulin resistance is the basis of its pathogenesis,and the body's inflammatory response is considered to be closely related to the occurrence and development of insulin resistance.The CIRBP/TLR4/MyD88/NF-κB signaling pathway is currently known as an important inflammatory pathway,which induces the body's inflammatory response by affecting the release of inflammatory factors,thereby causing insulin resistance.Therefore,this article reviews the research on the role of CIRBP/TLR4/MyD88/NF-κB signaling pathway in gestational diabetes mellitus,in order to provide new perspectives and new targets for clinical prevention and treatment of GDM.
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维普
