Study on the Mechanism of Jinkui Shenqi Pill in the Treatment of Alzheimer's Disease Based on Network Pharmacology
Objective To explore the potential mechanism of Jingui Shenqi pills in the treatment of Alzheimer's disease(AD)by network pharmacology.Methods The TCMSP database was used to screen the active chemical components of Jinkui Shenqi pills in the treatment of AD with oral bioavailability OB ≥30％and drug-like index DL≥0.18,and the chemical component targets were composed.The targets related to AD disease were obtained by Genecards database,and the potential targets of chemical component targets and disease targets in the treatment of AD were screened by Wayne analysis.Cytoscape was used to construct the"active ingredient-target"action network diagram,and the"ClusterProfiler"software package in R software was used for GO and KEGG pathway enrichment analysis.Results A total of 131 active ingredients and 216 chemical targets of Jinkui Shenqi pills were obtained,such as sitosterol,magnolin B,kadsura ketone,octylphenol,ethyl linolenic acid,alisol B,coptisine,etc.8718 AD-related protein genes were obtained from Genecards database.The 176 common targets of Jingui Shenqi pills and AD were obtained by Wayne analysis,including HSP90AA1,MAPK1,AKT1,JUN,RELA,FOS,ESR1,MAPK14,MYC,etc.GO analysis showed that the biological functions of the common targets were mainly involved in the response to oxidative stress,cell response to chemical stress,amide binding and other processes.KEGG enrichment mainly involved AGE-RAGE signaling pathway in body shear stress,atherosclerosis and diabetic complications.Conclusion The main active components of Jinkui Shenqi pill are sitosterol,magnolin B,kadsura ketone,wogonol,ethyl linolenic acid,alisol B,coptisine,etc.These components can play a role in the treatment of AD by HSP90AA1,MAPK1,AKT1,JUN,RELA,FOS,ESR1,MAPK14 and other key targets in the body shear stress and AGE-RAGE signaling pathway in atherosclerosis and diabetic complications.
万方数据
维普
