Intervention of Esketamine Combined with Serratus Anterior and Transverse Thoracic Muscle Plane Block on Postoperative Depression in Patients with Breast Cancer
Objective To investigate the effect of esketamine combined with serratus anterior and transverse thoracic plane block on postoperative depression in patients with breast cancer.Methods A total of 66 patients undergoing radical mastectomy in our hospital from October 2021 to February 2023 were selected and divided into group S and group C by random number table method,with 33 patients in each group.All patients underwent anterior serratus and transverse thoracic muscle plane block.Group C was the blank control group,and group S was added with esketamine during anesthesia induction,intraoperative and postoperative.The Hamilton Depression Scale(HAMD-17)score at different time points[1 day before operation(T0.5),3 days after operation(Ti),7 days after operation(T2)and 1 month after operation(T3)],Pittsburgh Sleep Quality Index(PSQI)scores at T0,T0.5,T1 and T2,Visual Analogue Scale(VAS)score at T0.5,T1 and T2,serum brain-derived neurotrophic factor(BDNF)and 5-hydroxytryptamine(5-HT)concentrations at T0,T0.5 and T1 were compared between the two groups.The operation time,nausea and vomiting were recorded.Results The HAMD-17 score of group S at Ti,T2 and T3 were lower than those of group C(P＜0.05).The PSQI scores at T0.5,T1 and T2 in group S were lower than those in group C(P＜0.05).The serum levels of BDNF and 5-HT at T0.5 and T1 in group S were higher than those in group C(P＜0.05).There was no significant difference in VAS scores at T0.5,T1 and T2,operation time and incidence of nausea and vomiting between group S and group C(P＞0.05).Conclusion Esketamine combined with serratus anterior and transverse thoracic plane block can reduce the incidence of depression and improve the quality of sleep in patients after breast cancer surgery.
万方数据
维普
