Diagnostic Efficacy of Serum AFP,GP73 and PIVKA-Ⅱ in Primary Liver Cancer
Objective To study the diagnostic efficacy of single and combined detection of serum alpha-fetoprotein(AFP),Golgi 73(GP73)and abnormal prothrombin(PIVKA-Ⅱ)in primary liver cancer.Methods A total of 132 patients with primary liver cancer diagnosed in our hospital from January to December 2021 were selected as the primary liver cancer group,92 patients with hepatitis,liver fibrosis and cirrhosis were selected as the benign control group,and 99 healthy subjects were selected as the healthy control group.The levels of serum AFP,GP73 and PIVKA-Ⅱ in the three groups were analyzed by magnetic particle chemical immunoluminescence method,and the differences between the groups were compared.The diagnostic value of AFP,GP73 and PIVKA-Ⅱ in primary liver cancer was analyzed by receiver operating characteristic(ROC)curve.Results The levels of serum AFP,GP73 and PIVKA-Ⅱ in primary liver cancer group were higher than those in benign control group and healthy control group(P＜0.05).The specificity of serum AFP,GP73 and PIVKA-Ⅱ in the detection of primary liver cancer was 96.93％,70.72％and 93.22％,respectively;the sensitivity was 51.90％,81.51％and 75.91％,respectively;the AUC was 0.77,0.80 and 0.88,respectively,thus serum PIVKA-Ⅱ had high sensitivity,specificity and AUC.The specificity,sensitivity and AUC of the combined diagnosis of primary liver cancer were 88.89％,83.24％and 0.90,respectively,which were higher than those of single detection(P＜0.05).Conclusion The combined detection of AFP,GP73 and PIVKA-Ⅱ can improve the detection rate of primary liver cancer and reduce the rate of missed diagnosis.
Alpha-fetoproteinGolgi apparatus 73Abnormal prothrombinPrimary liver cancer
万方数据
维普
