Research Progress of miR-520a-5p in Preeclampsia and Fetal Growth Restriction
Preeclampsia(PE)and fetal growth restriction(FGR)are serious pregnancy complications in which the formation of placental pathological structures begins in the early stage of pregnancy,and several months earlier than the clinical diagnosis time.microRNA 520a-5p(miR-520a-5p)is specifically expressed in placental trophoblast cells,and its abnormal expression is closely related to PE and FGR.MiR-520a-5p can be isolated from exosomes secreted by placental trophoblast cells.The expression of miR-520a-5p in serum placental exosomes of PE and FGR patients in early pregnancy is significantly different from that of normal pregnancy,and is consistent with the expression of miR-520a-5p in placental tissues after termination of pregnancy in late pregnancy.It has high accuracy for predicting subsequent PE and FGR in early pregnancy.Therefore,miR-520a-5p in serum placental exosomes in early pregnancy is expected to be a new biomarker for PE and FGR.This article reviews the research of miR-520a-5p in PE and FGR,in order to provide reference for clinical diagnosis.
万方数据
维普
