Meta-analysis of the Prognostic Value of Pre-treatment NLR in Patients with Non-small Cell Lung Cancer Treated with ICIs
Objective To explore the prognostic value of pre-treatment NLR in NSCLC patients treated with ICIs by Meta-analysis.Methods A systematic search of Chinese databases(CNKI,VIP,Wanfang)and English databases(EMbase,PubMed,The Cochrane Library)from the establishment of the database to June 2022 was conducted to retrieve the literature on the relationship between pre-treatment NLR and the prognosis of NSCLC patients treated with ICIs.The NOS score scale was used to evaluate the quality of the literature.STATA 15.0 statistical software was used for meta-analysis.Results Finally,24 Chinese and English literatures were included,with a total of 2471 patients.High NLR was associated with shorter PFS(HR:1.82,95％CI:1.61-2.05)and poorer OS(HR:2.52,95％CI:2.18-2.90)in patients treated with ICIs,the results of subgroup analysis were consistent with the combined results(P＜0.001).Conclusion NLR before treatment can be used as a potential prognostic biomarker for NSCLC patients treated with ICIs.
Non-small cell lung cancerNeutrophil to lymphocyte ratioImmune checkpoint inhibitors
万方数据
维普
