Correlation Between Background Parenchymal Enhancement and Different Molecular Subtypes of Breast Cancer
Objective To explore the correlation between background parenchymal enhancement(BPE)and different molecular subtypes of breast cancer.Methods The first phase BPE levels of 57 patients with breast cancer who were admitted to Lu'an Hospital Affiliated to Anhui Medical University from October 2019 to March 2023 were retrospectively analyzed.According to the fifth edition of the Breast Imaging and Reporting Data System(BIRADS),BPE was classified into four types:type a(minimal enhancement),type b(mild enhancement),type c(moderate enhancement),and type d(significant enhancement).According to the expression results of the immunohistochemical markers estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor(HER-2),and cell proliferation related antigen Ki-67,breast cancer was divided into four subtypes:Luminal A,Luminal B,HER-2 overexpression and triple negative.The differences between BPE levels and different immunohistochemical markers and molecular subtypes of breast cancer were compared,and the correlation between BPE levels and age and menopausal status was analyzed.Results Among 57 cases of breast cancer,17 cases were Luminal A type,21 cases were Luminal B type,12 cases were HER-2 overexpression type,and 7 cases were triple negative.The level of BPE was negatively correlated with age(r=-0.299,P=0.024)and menopausal status(r=-0.398,P=0.002).The immunohistochemical marker PR of breast cancer was related to qualitative BPE(P=0.043).The immunohistochemical markers ER,HER-2,Ki-67 and four different molecular subtypes of breast cancer were not related to qualitative BPE.Conclusion BPE may be used as an imaging marker for evaluating the prognosis of breast cancer and provide guidance for the treatment of breast cancer.
Breast cancerBackground parenchymal enhancementMolecular subtype
万方数据
维普
