Study on the Expression of CD35,CD44,CD58 and CD59 in Red Blood Cells of Patients with Chronic Mountain Sickness
Objective To study the expression of immune molecules CD35,CD44,CD58 and CD59 on the surface of red blood cells in peripheral blood of patients with CMS.Methods CMS patients who were admitted to the Affiliated Hospital of Qinghai University from November 2019 to January 2021 were selected as CMS group,and healthy people(normal blood picture)in the physical examination center of the Affiliated Hospital of Qinghai University were selected as normal control group.The subjects of the two groups were Han men who lived at an altitude of 2500-4500 m for a long time,with 20 men in each group.Flow cytometry was used to detect the expression of CD35,CD44,CD58 and CD59 on the surface of mature red blood cells in peripheral blood of CMS patients.At the same time,some red blood cells were isolated to determine their rapid natural immune adhesion to tumor cells.The clinical data of the two groups were compared.Results The positive expression rates of CD35 and CD44 on the surface of peripheral blood red blood cells in the CMS group were lower than those in the normal control group,and the difference was statistically significant(P＜0.05).The tumor erythrocyte rosette rate in the CMS group was lower than that in the normal control group,and the difference was statistically significant(P＜0.05).The positive expression rates of CD44,CD35,CD58 and CD59 on the surface of peripheral blood red blood cells in 5 CMS patients who lived at an average altitude of 4500 m for a long time were lower than those in 15 CMS patients who lived at an average altitude of 3250 m for a long time,but the difference was not statistically significant(P＞0.05).Conclusion The decrease of erythrocyte immune function in patients with chronic mountain sickness may be related to the decrease of resistance and the occurrence of infection.
万方数据
维普
