The Level and Clinical Significance of Serum ANGPTL8 in Patients with Type 2 Diabetic Retinopathy
Objective To investigate the correlation between serum angiopoietin-like protein 8(ANGPTL8)levels and the severity of type 2 diabetic retinopathy by quantifying its level.Methods Sixty patients with type 2 diabetes mellitus who were admitted to the Department of Endocrinology of the First Hospital of Harbin Medical University from October 2018 to January 2019 were selected.According to the presence or absence of diabetic retinopathy and its stage,they were divided into simple diabetes group(DM group),non-proliferative diabetic retinopathy group(NPDR group),and proliferative diabetic retinopathy group(PDR group),with 20 patients in each group.At the same time,20 normal subjects at the same time were selected as the control group(CG group).The basic data of the enrolled patients were collected,and biochemical indicators such as glycated hemoglobin(HbA1c),fasting C-peptide,fasting venous glucose(FBG),total cholesterol(TC),and triglyceride(TG)were measured.Serum ANGPTL8 levels were measured by ELISA.Results There was no significant difference in systolic blood pressure,diastolic blood pressure,BMI,C-peptide and TC among the four groups(P＞0.05).The course of diabetes increased gradually among DM group,NPDR group and PDR group,and that in PDR group was higher than that in DM group and NPDR group;HbA1c and FBG in DM group,NPDR group and PDR group were higher than those in CG group;the level of TG increased gradually among CG group,DM group,NPDR group and PDR group,and the level of TG in PDR group,NPDR group and DM group was higher than that in CG group(P＜0.05).The concentration of serum ANGPTL8 in CG group,DM group,NPDR group and PDR group increased gradually,and that in the PDR group was higher than the other three groups,the difference was statistically significant(P＜0.05),and the increase of serum ANGPTL8 was related to TG(P＜0.05).Conclusion ANGPTL8 has a certain correlation with the severity of diabetic retinopathy.It may be involved in the occurrence and development of PDR by affecting TG metabolism on the basis of abnormal glucose metabolism.
万方数据
维普
