Objective To investigate the efficacy and safety of urokinase(UK)thrombolysis in patients with acute cerebral infarction(ACI)4.5-6 h after onset.Methods The clinical data of 128 patients with ACI admitted to our hospital from January 2020 to December 2022 were retrospectively analyzed.According to the results of modified Rankin scale(mRS)at discharge,the patients were divided into good prognosis group(mRS ≤2 scores,n=78)and poor prognosis group(mRS＞2 scores,n=50).The clinical data of the two groups were compared,and the risk factors affecting the prognosis of patients were analyzed by multivariate Logistic analysis.Results There were significant differences in disturbance of consciousness,poor blood glucose control,symptomatic intracranial artery stenosis and onsetto treatment time(OTT)between the two groups(P＜0.05).Logistic analysis showed that disturbance of consciousness,poor blood glucose control and OTT were all factors leading to poor prognosis in ACI patients.There was a statistically significant difference in mRS between admission and discharge of ACI patients(P＜0.05).Conclusion UK thrombolysis in patients with ACI at 4.5-6 h can significantly improve neurological function and reduce disability rate,with low risk of bleeding,no serious complications,and relatively safe.
关键词
急性脑梗死/尿激酶/溶栓/意识障碍/血糖/症状性颅内动脉狭窄/发病-治疗时间
Key words
Acute cerebral infarction/Urokinase/Thrombolysis/Consciousness disorder/Blood glucose/Symptomatic intracranial artery stenosis/Onset to treatment time
维普
万方数据