Objective To investigate the expression level and clinical significance of Th1/Th2 related cytokines in peripheral blood of patients with chronic hepatitis B(CHB).Methods A total of 56 CHB patients admitted to the Second Affiliated Hospital of Dali University from January 2022 to February 2023 were selected as the study group,and 31 healthy peers at the same time were selected as the control group.The study group was divided into HBeAg(+)group and HBeAg(-)group according to the results of two pairs of semi-hepatitis B test.With the viral load of 104 copies/ml as the boundary value,the HBeAg(+)group was further divided into high viral load group(＞104 copies/ml)and low viral load group(＜104 copies/ml).The expression levels of Th 1/Th2-related cytokines in peripheral blood of the study group and the control group were detected,and the results of Th1/Th2-related cytokines in HBeAg(+)group and HBeAg(-)group were compared.The difference of Th 1/Th2-related cytokine levels between high viral load group and low viral load group in HBeAg(+)group was further analyzed.Results The levels of IFN-y,IL-2,IL-4 and IL-5 in peripheral blood of the study group were higher than those of the control group,and the differences were statistically significant(P＜0.05).In the study group,the levels of IFN-γ and IL-2 in peripheral blood of HBeAg(+)group were lower than those in HBeAg(-)group,while the levels of IL-4 and IL-5 in peripheral blood were higher than those in HBeAg(-)group,the differences were statistically significant(P＜0.05).The levels of IFN-γ,IL-2,IL-4 and IL-5 in peripheral blood of low viral load group in HBeAg(+)group were lower than those in high viral load group,and the differences were statistically significant(P＜0.05).Conclusion CHB patients have immune regulation dysfunction.The detection of Th1/Th2 related cytokines in peripheral blood of CHB patients has important reference value for the diagnosis,severity and prognosis of the disease.
关键词
乙型病毒性肝炎/IFN-γ/IL-2/IL-4/IL-5/免疫功能/Th1/Th2相关细胞因子
Key words
Viral hepatitis B/IFN-γ/IL-2/IL-4/IL-5/Immune function/Th1/Th2 related cytokines
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