Effect of Fluconazole Combined with Clotrimazole Vaginal Suppository in the Treatment of Fungal Vaginitis and its Effect on the Improvement of Clinical Symptoms
Objective To study the effect of fluconazole combined with clotrimazole vaginal suppository in the treatment of fungal vaginitis and its effect on the improvement of clinical symptoms.Methods A total of 68 patients with mycotic vaginitis diagnosed and treated in our hospital from April 2020 to April 2022 were selected as the research objects.They were divided into control group and observation group by random number table method,with 34 patients in each group.The control group was treated with clotrimazole vaginal suppository,and the observation group was treated with fluconazole on the basis of the control group.The clinical efficacy,clinical symptom score,disappearance time of clinical symptoms,incidence of adverse reactions and recurrence rate were compared between the two groups.Results The total effective rate of treatment in the observation group was 91.18％,which was higher than 79.41％in the control group(P＜0.05).The clinical symptom scores of the two groups after treatment were lower than those before treatment,and the observation group was lower than the control group(P＜0.05).The disappearance time of urination pain,leucorrhea abnormality,vulva pruritus and vulva swelling in the observation group was shorter than that in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P＞0.05).After 3 and 6 months of follow-up,the recurrence rate of the observation group was lower than that of the control group(P＜0.05).Conclusion Fluconazole combined with clotrimazole vaginal suppository is effective in the treatment of fungal vaginitis.It can reduce clinical symptoms,shorten the disappearance time of clinical symptoms,reduce the recurrence rate,and will not increase clinical adverse reactions,which is an effective,feasible and safe treatment.
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