A Clinical Study on the Treatment of Senile Hypertension Complicated with Chronic Cardiac Insufficiency by Ningroxinto,Betaloc Combined with Nifedipine
Objective To analyze the effects of norfloxacin and irbesartan combined with betaloc and nifedipine respectively on the structure and function of right atrium in elderly patients with hypertension and chronic cardiac insufficiency.Methods A total of 180 elderly patients with hypertension and chronic heart failure admitted to our hospital from October 2021 to October 2022 were selected.According to the random number table method,they were divided into the noxintuo group(treated with noxintuo,betaloc and bay intong)and the irbesartan group(treated with irbesartan,betaloc and bayintong),with 90 patients in each group.The clinical efficacy and drug safety of the two groups were compared.The changes of blood pressure level,NT-proBNP level,cardiac function(LVEF,TAPSE,right ventricular lateral wall systolic displacement velocity,PASP)and right atrial structure(RAVlt,RAVIa,RAVIp,RAVpEF,RAVaEF,RAVtEF)before and after treatment were compared between the two groups.Results The significant effective rate of nuoxintuo group(81.11％)was higher than that of irbesartan group(66.67％)(P＜0.05).However,there was no significant difference in the total effective rate between the two groups(P＞0.05).After treatment,the SBP and DBP values of the nuoxintuo group were higher than those of the irbesartan group,and the NT-proBNP value was lower than that of the irbesartan group(P＜0.05).After treatment,the systolic displacement velocities of LVEF,TAPSE and right ventricular wall,PSAP in the nuoxintuo group were higher than that in the irbesartan group(P＜0.05).After treatment,the levels of RAVlt,RAVIa,and RAVIp in the nuoxintuo group were lower than those in the irbesartan group,while the levels of RAVpEF,RAVaEF,and RAVtEF in the nuoxintuo group were higher than those in the irbesartan group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups during the treatment(P＞0.05).Conclusion Nuoxintuo and irbesartan combined with betaloc and nifedipine respectively can effectively treat hypertension combined with chronic cardiac insufficiency,with high safety.However,norgestimate is more conducive to improving the left atrial structure and function,as well as cardiac function.
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