Clinical Effect of High Flux Hemodialysis Combined with Gabapentin in the Treatment of Restless Leg Syndrome in Hemodialysis Patients
Objective To observe the clinical effect of high flux hemodialysis(HFHD)combined with gabapentin in the treatment of restless legs syndrome(RLS)in maintenance hemodialysis patients.Methods From June 2021 to February 2022,40 patients with regular hemodialysis who met the diagnostic criteria of RLS in the blood purification center of Dejiang County People's Hospital were selected as the research objects.The patients were divided into observation group and control group by random grouping method,with 20 patients in each group.The control group was treated with routine hemodialysis,and the observation group was treated with HFHD combined with gabapentin.The clinical efficacy,International Restless Legs Syndrome Study Group(IRLSSG)score,Pittsburgh Sleep Quality Index(PSQI)score,blood β2-microglobulin(β2-MG),intact parathyroid hormone(iPTH),single partment urea clearance index(Kt/V)level and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group(P＜0.05).After treatment,the IRLSSG score,PSQI score,β2-MG and iPTH levels in the observation group were lower than those in the control group,and the Kt/V level was higher than that in the control group(P＜0.05).Both groups had no serious adverse reactions.Conclusion HFHD combined with gabapentin in hemodialysis patients can reduce the levels ofβ2-MG and iPTH,improve RLS symptoms and sleep quality of patients,which is worthy of clinical application.
High flux hemodialysisGabapentinHemodialysisRestless legs syndrome
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维普
