Study on the Correlation Between UCP1 Gene Polymorphism and Peripheral Vascular Disease in Patients with Diabetes Mellitus
Objective To investigate the relationship between UCP1 polymorphism and peripheral vascular disease in patients with diabetes mellitus.Methods From July 2019 to July 2020,440 patients with diabetes mellitus were enrolled in this study.The ankle-brachial index ≤0.9 was selected as he peripheral vascular disease group,with a total of 207 patients.The ankle-brachial index was 0.9-1.4 were as the control group,with total of 233 patients.DNA was extracted from whole blood,and UCP1 gene polymorphism was detected by SNaPshot method.The relationship between UCP1 gene polymorphism and peripheral vascular disease and common risk factors were analyzed.MDR software was used to analyze the interaction between gene and environmental factors.Results There was no significant difference in BMI,SBP,DBP,TG,TC,LDL and NA between the two groups(P＞0.05),while there were significant differences in the course of disease,FBS,HbA1c,HDL and smoking history between the two groups(P＜0.05).Long duration of diabetes mellitus and smoking were independent risk factors for peripheral vascular disease in diabetic patients(P＜0.05).After adjusting the course of disease,FBS,HbA1c,HDL,smoking rs1800592 AA was 1.824 times higher than that of GG patients with peripheral vascular disease(OR=1.824,P＜0.05).The rs45539933 and rs10011540 gene polymorphisms were not associated with the risk of peripheral vascular disease(P＞0.05).The three interaction models of course of disease,smoking and rs1800592 were statistically significant(P＜0.05).Conclusion UCP1 gene polymorphism is associated with the incidence of peripheral vascular disease in patients with diabetic mellitus.The interaction of rs1 800592 with smoking and long course of disease mellituspromotes the occurrence of diabetic peripheral vascular disease.
Peripheral vascular diseaseUncoupling protein 1High-density lipoproteinHemoglobin
万方数据
维普
