Relationship Between the Loss of Mismatch Repair Protein Expression and the Pathological Feature and Prognosis of Colorectal Cancer
Objective To investigate the relationship between the expression of mismatch repair protein and the pathological characteristics and prognosis of colorectal cancer.Methods A total of 190 patients with colorectal cancer with complete clinical and pathological data who were treated in People's Hospital of Chaozhou City from September 2016 to September 2022 were included in the analysis.The expression of MLH1,MSH2,MSH6 and PMS2 in pathological specimens was detected by immunohistochemistry.One of the expression deletions was dMMR group,and all of them were divided into pMMR group.The pathological characteristics and prognosis of the two groups were analyzed.Results The total deletion rate of mismatch repair protein was 21.58％.The tumor size,location,lymph node metastasis,tumor pathological stage of the two groups were correlated with the expression of mismatch repair protein(P＜0.05),while there was no correlation between the expression of mismatch repair protein and the histological type of tumor,the degree of tumor differentiation,nerve and/or vascular invasion(P＞0.05).Kaplan-Meier analysis showed that the disease-free survival time and overall survival time of patients in the dMMR group were better than those in the pMMR group,and the difference was statistically significant(P＜0.05).Conclusion The expression of mismatch repair protein is closely related to the tumor size,location,lymph node metastasis and pathological stage of colorectal cancer.At the same time,the disease-free survival time and total survival time of patients with mismatch repair protein deletion are also longer,suggesting a better prognosis.
万方数据
维普
