Analysis of Clinical and Pathological Characteristics of IgA Nephropathy Patients with Different Proteinuria Levels
Objective To investigate the clinical and pathological features of primary IgA nephropathy patients with different proteinuria levels.Methods A total of 204 patients with IgA nephropathy diagnosed by renal biopsy in the First Affiliated Hospital of Shihezi University School of Medicine from January 2010 to December 2021 were selected.According to the level of 24-hour urinary protein quantification,the patients were divided into 4 groups:＜0.3 g/d(group A,48 patients),0.3-0.99 g/d(group B,67 patients),1-1.99 g/d(group C,43 patients),≥2 g/d(group D,46 patients).The clinical data of the four groups were compared,and the relationship between urinary protein quantification and clinical indicators was analyzed by Spearman correlation.Kaplan-Meier curve was used to analyze the cumulative survival rate of kidney.Results ①There were significant differences in albumin(ALB),total protein(TP),creatinine(Scr),urea nitrogen(BUN),estimated glomerular filtration rate(eGFR),total cholesterol(TC),serum IgG,Oxford classification and WHO classification among the four groups(P＜0.05);②Spearman correlation analysis showed that with the decrease of ALB,TP,eGFR,IgG and the increase of Scr,BUN and TC,the quantitative level of 24-hour urine protein increased;③Kaplan-Meier curve analysis showed that the cumulative survival rate of kidney in group A was higher than that in group B,group C and group D,and the cumulative survival rate of kidney in group D was lower than that in group B and group C.Conclusion There is a close relationship between the pathological grade of IgA nephropathy and clinical indicators.With the increase of urinary protein quantification,the renal function of patients with IgA nephropathy decreases,the degree of pathological damage increases,and the cumulative survival rate of kidney decreases.
IgA nephropathyClinical characteristics24-hour urinary protein quantificationWHO classificationEstimate glomerular filtration rate
万方数据
维普
