Correlation Between Vitamin D and Recurrent Spontaneous Abortion and its Predictive Value for Pregnancy Outcome
Objective To study the relationship between vitamin D and recurrent spontaneous abortion(RSA),and to explore the predictive value of vitamin D on the pregnancy outcome of RSA patients.Methods From June 2020 to June 2021,120 patients with RSA who were regularly surrounded in the Second Affiliated Hospital of Zhengzhou University were selected as the RSA group,and 50 normal pregnant women were selected as the control group.Serum vitamin D levels were compared between the two groups,as well as vitamin D levels in RSA group with different pregnancy outcomes and abortion times.Logistic regression was used to analyze the risk relationship between vitamin D level and RSA.ROC curve was used to analyze the predictive value of vitamin D on pregnancy outcome of recurrent spontaneous abortion.Results The levels of 25(OH)D in the RSA group and the control group were(14.92±7.01)ng/ml and(20.81±9.69)ng/ml,respectively,the difference between the two groups was statistically significant(P＜0.05).The proportion of vitamin D sufficiency and insufficiency in the RSA group was lower than that in the control group,and the proportion of deficiency and severe deficiency was higher than that in the control group,with statistically significant differences(P＜0.05).The levels of 25(OH)D in continuing pregnancy and abortion in RSA group were(15.93±7.05)ng/ml and(12.48±6.38)ng/ml,respectively,and the difference between the two groups was statistically significant(P＜0.05).There was significant difference in 25(OH)D level among different abortion times(P＜0.05).Logistic regression analysis showed that vitamin D deficiency was an independent risk factor for RSA.ROC curve analysis showed that vitamin D had a certain value in predicting recurrent abortion in RSA patients,the area under the curve was 0.678,and the cut-off value,sensitivity and specificity were 11.86 ng/ml,70.60％and 60.00％,respectively.Conclusion The vitamin D level of pregnant women is generally deficient.Compared with normal pregnant women,the serum vitamin D level of RSA patients in early pregnancy is lower.When vitamin D＜11.86 ng/ml in early pregnancy,RSA patients have a higher risk of recurrent abortion.
万方数据
维普
