Effect of Tenofovir Disoproxil in the Treatment of Hepatitis B and its Effect on Recurrence Rate
Objective To observe the clinical effect of tenofovir disoproxil in the treatment of hepatitis B and its effect on recurrence rate.Methods A total of 72 patients with hepatitis B diagnosed and treated in our hospital from December 2021 to December 2022 were selected as the research objects.They were divided into control group and observation group by random number table method,with 36 patients in each group.The control group was treated with entecavir,and the observation group was treated with tenofovir disoproxil.The clinical effect,HBV-DNA negative conversion rate,HBeAg negative conversion rate,liver function index[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TbiL)],incidence of adverse reactions and recurrence rate were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.44％,which was higher than 80.56％in the control group(P＜0.05).The negative conversion rates of HBV-DNA and HBeAg in the observation group were higher than those in the control group(P＜0.05).After treatment,ALT,AST and TbiL in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P＜0.05).The incidence of adverse reactions in the observation group was 8.33％,which was lower than 19.44％in the control group(P＜0.05).After 3 months of follow-up,the recurrence rate of the observation group was 11.11％,which was lower than 25.00％of the control group(P＜0.05).Conclusion Tenofovir disoproxil can improve the therapeutic effect of patients with hepatitis B,improve their liver function,promote the negative conversion of HBV-DNA and HBeAg,reduce the incidence of adverse reactions and recurrence rate,and has ideal long-term clinical efficacy.
万方数据
维普
