Analysis of the Efficacy and Toxicity of Olaparib Combined with TP Chemotherapy in the Treatment of Patients with Advanced Ovarian Cancer
Objective o investigate the efficacy and toxicity of olaparib combined with TP chemotherapy in the treatment of patients with advanced ovarian cancer(OC).Methods A total of 96 patients with advanced OC admitted to the Department of Oncology,Chengwu County People's Hospital from May 2021 to May 2022 were selected as the research objects.They were divided into control group(48 patients)and observation group(48 patients)by random number table method.The control group was treated with TP chemotherapy,and the observation group was treated with olaparib on the basis of TP chemotherapy.The short-term efficacy,tumor markers[human epididymis protein 4(HE4),carbohydrate antigen(CA125,CA199)],toxic and side effects and recurrence(biochemical recurrence rate,clinical recurrence rate)were compared between the two groups.Results The objective remission rate and disease control rate of the observation group were higher than those of the control group(P＜0.05).After treatment,the levels of HE4,CA125 and CA199 in the two groups were lower than those before treatment,and the levels of HE4,CA125 and CA199 in the observation group were lower than those in the control group(P＜0.05).The incidence of adverse reactions in the observation group was higher than that in the control group(P＜0.05).After 6 months of treatment,the biochemical recurrence rate and clinical recurrence rate in the observation group were lower than those in the control group(P＜0.05).Conclusion Olaparib combined with TP chemotherapy is effective in the treatment of advanced OC,which can improve its short-term efficacy,down-regulate the level of tumor markers and reduce the risk of recurrence,but the toxicity are increased.
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