Network Pharmacology Study on the Mechanism of Wutou Decoction in the Treatment of Lumbar Disc Herniation
Objective To explore the mechanism of Wutou decoction in the treatment of lumbar disc herniation(LDH)by using network pharmacology and molecular docking technology.Methods TCMSP was used to screen out the effective active ingredients and target information of Wutou decoction,and convert them into corresponding gene names;the targets of LDH were obtained from the GeneCard and OMIM databases,and the common targets of the two were obtained by Venny plot.Cytscape was used to construct a"Chinese medicine-active ingredient-disease target"and PPI network diagram,and R software was used to perform GO and KEGG enrichment analysis.Finally,molecular docking of effective active ingredients and key targets was performed.Results A total of 151 effective active components and 52 common targets of Wutou decoction in the treatment of LDH were obtained.The results of the network diagram showed that the core active components included quercetin,kaempferol,luteolin,etc.,and the key targets included IL6,TNF,AKT1,IL1 B,VEGFA,MMP9,etc.The KEGG pathway mainly involved AGE-RAGE,IL-17,TNF and other signaling pathways.The results of molecular docking showed that the binding between the effective active components and the key targets was good.Conclusion Wutou decoction treats LDH through multi-component,multi-target and multi-pathway,which can provide basis and ideas for the follow-up clinical application and research of Wutou decoction.
国家科技期刊平台
NSTL
万方数据
维普
