5-HTR1A基因rs6295多态性与抑郁症伴自伤行为的相关研究
Related Research on rs6295 Polymorphism of 5-HTR1A Gene and Depression with Self-injury Behavior
郁德波 1林志雄 2林举达2
作者信息
- 1. 广东医科大学第一临床医学院,广东 湛江 524001
- 2. 广东医科大学附属医院精神心理科,广东 湛江 524001
- 折叠
摘要
抑郁症是一种高发病率的慢性疾病,然而对抑郁症的病因及发病机制的了解仍然不足,其强大的遗传能力和遗传基础已从家庭、双胞胎和收养研究中得到很好的证实,5-HTR1A启动子的rs6295多态性与抑郁症伴自伤行为有关.本文就5-HTR1A基因rs6295多态性与抑郁症伴自伤行为之间的发病机制、研究现况和治疗进展进行综述,以期为预测抑郁障碍伴NSSI的遗传易感性提供参考依据.
Abstract
Depression is a chronic disease with high incidence.However,the etiology and pathogenesis of depression are still poorly understood.Its strong genetic ability and genetic basis have been well confirmed by family,twin and adoption studies,suggesting that rs6295 polymorphism of 5-HTR1A promoter is associated with depression with self-injury behavior.This article reviews the pathogenesis,research status and treatment progress of rs6295 polymorphism of 5-HTR1A gene and depression with self-injury behavior,in order to provide a reference for predicting the genetic susceptibility of depression with NSSI.
关键词
人5-羟色胺受体1A/抑郁症/自伤行为/基因多态性Key words
Human serotonin receptor 1A/Depression/Self-injury behavior/Gene polymorphism引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据