Research Status of Vaginal Microecology,Bacterial Vaginosis and Cervical Human Papillomavirus Infection
Vaginal microecology plays an important role in women's reproductive health,and its imbalance or change can lead to the occurrence of various gynecological diseases.When the content of Lactobacillus in the vaginal flora decreases and the content of Gardnerella increases,bacterial vaginosis will occur.Persistent infection of cervical high-risk human papillomavirus(HPV)is an important factor in inducing cervical lesions,especially cervical cancer.Studies have confirmed that changes in vaginal microecology and bacterial vaginosis are associated with HPV acquisition and persistent infection.Therefore,clarifying the relationship between HPV infection and vaginal microecology can provide new ideas for the prevention of diseases related to HPV infection.At present,the concept of"probiotics and probiotics-related preparations regulating vaginal microorganisms"provides a new research concept for restoring normal vaginal microecology.Based on the vaginal microecology,this paper demonstrates the causal relationship between the changes of vaginal flora and bacterial vaginosis,and reviews the correlation between vaginal flora,anatomical structure,endocrine changes and local immunity and HPV infection,aiming to provide new ideas for the prevention and treatment of diseases related to HPV infection.