The Mechanism of Prunella Vulgaris L.in the Treatment of Hyperplasia of Mammary Gland Based on Network Pharmacology and Molecular Docking
Objective To explore the mechanism of Prunella vulgaris L.in the treatment of hyperplasia of mammary gland based on network pharmacology and molecular docking technology.Methods TCMSP database and GeneCards database were used to obtain compounds and disease-related targets.String database and Cytoscape 3.8.2 software were used to construct protein interaction network.R software was used to analyze GO function and KEGG pathway enrichment.Finally,AutoDock Vina software was used for molecular docking verification.Results A total of 13 active ingredients and 117 potential targets were screened out.The potential targets involved biological processes such as stress response,signal transduction,transcriptional regulation and cell cycle regulation,as well as estrogen signaling pathway and other pathways closely related to breast hyperplasia.Molecular docking results showed that AKT,MAPK1,CREB,PGR and corresponding active components in the estrogen signaling pathway could form a stable conformation.Conclusion Prunella vulgaris L.plays a role in the treatment of hyperplasia of mammary gland through multi-component,multi-target and multi-channel synergy.
Prunella vulgaris L.Hyperplasia of mammary glandNetwork pharmacologyMolecular dockingEstrogen signaling pathway
万方数据
维普
