A Survey of Public Awareness and Willingness to Participate in Healthy Subjects
Objective To understand the public awareness and willingness to participate in healthy subjects,and to provide reference for better carrying out and promoting the high-quality development of drug clinical trials.Methods From April to May 2022,a questionnaire survey was conducted in the First Affiliated Hospital of Naval Medical University to investigate the public awareness and willingness to participate in healthy subjects.The results were analyzed by SPSS 23.0 software.Results A total of 448 valid questionnaires were collected.86.16％of the respondents had a good understanding of the healthy subjects.There were statistically significant differences in educational background,economic pressure,annual income,medical insurance and trust in the researchers among the respondents with different level of perception(P＜0.05).Only 15.18％of the respondents were willing to become healthy subjects,67.65％of whom were primarily motivated by wanting to contribute to medicine and 52.94％of whom were primarily motivated by helping patients obtain new diagnosis and treatment methods.52.46％of the respondents were unwilling to become healthy subjects,74.04％of whom mainly for the family worried,followed by 64.68％of whom mainly for the side effects of drugs.However,when the financial compensation of the trial was increased to the psychological expectation of respondents,41.70％of the unwilling subjects changed their attitudes and agreed.Another 32.36％of the respondents held an uncertain attitude,80.69％of whom were because of worried about drug side effects,67.59％and 61.38％of whom were because of that the safeguard measures after the injury and they did not know the test content,respectively.However,when their parents and family supported their participation,78.62％of the uncertain people would also choose to agree.There were significant differences in age,nationality and trust in researchers among the respondents with different willingness to participate(P＜0.05).Conclusion The public's overall awareness of healthy subjects is high,but their willingness to participate is low.Educational background,economic pressure,annual income,medical insurance benefits and trust in researchers are the demographic factors that affect the public perception of healthy subjects.The reasons that affect the willingness of the public to participate include:the attitude of family members,drug side effects,economic compensation,clinical trial content and risk measures,among which family factors and drug safety factors are important factors for the public to consider.Age,nationality and trust in researchers are the demographic factors that affect public participation in healthy subjects.The targeted popular science education on drug clinical trials should be undertaken based on the public needs,to make family factors play a role in healthy subject activity,improve the legislation on the protection of the rights and interests of healthy subjects in China,and improve the enthusiasm of the public to participate in drug clinical trials.
Health subjectsPhase Ⅰ clinical trial of drugsAwarenessPaiticipation willingness
万方数据
维普
