Observation on the Efficacy of Self-made Fuzheng Xiaozheng Decoction Combined with Furoquintinib and Sintilimab in the Treatment of Advanced Colorectal Cancer After Standard Treatment Failure
Objective To observe the clinical efficacy of self-made Fuzheng Xiaozheng decoction combined with furoquintinib and sintilimab in the treatment of advanced colorectal cancer after standard treatment failure.Methods A total of 45 patients with advanced colorectal cancer after standard treatment failure in our hospital from October 2019 to December 2022 were randomly divided into control(n=23)and treatment(n=22)groups.The control group was treated with furoquinitinib+sintilimab,and the treatment group was treated with self-made Fuzheng Xiaozheng decoction on the basis of the control group.The clinical efficacy,quality of life(QOL)and adverse reactions were compared between the two groups.Results The disease control rate of the treatment group was 59.09％,compared with 52.17％of the control group,the difference was not statistically significant(P＞0.05);after treatment,the QOL score of the treatment group and the control group was(40.65±5.90)scores and(29.30±4.38)score,respectively,which was higher than(20.31±2.70)scores and(19.39±3.12)scores before treatment,and the treatment group was higher than the control group(P＜0.05).The incidence of adverse reactions in the treatment group was lower than that in the control group(P＜0.05).Conclusion For patients with advanced colorectal cancer after standard treatment failure,self-made Fuzheng Xiaozheng decoction combined with furoquintinib+sintilimab regimen can improve the disease control rate to a certain extent,improve the quality of life of patients,reduce adverse reactions,and provide favorable conditions for the good survival of patients.
Fuzheng Xiaozheng decoctionFuroquintinibSintilimabStandard treatmentAdvanced colorectal cancer
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